The improvement of the loading content of hydrophilic drugs by polymer nanoparticles\n(NPs) recently has received increased attention from the field of controlled release. We developed a\nnovel, simply modified, drop-wise nanoprecipitation method which separated hydrophilic drugs\nand polymers into aqueous phase (continuous phase) and organic phase (dispersed phase), both\nindividually and involving a mixing process. Using this method, we produced ciprofloxacin-loaded\nNPs by Poly (d,l-lactic acid)-Dextran (PLA-DEX) and Poly lactic acid-co-glycolic acid-Polyethylene\nglycol (PLGA-PEG) successfully, with a considerable drug-loading ability up to 27.2 wt% and an\nin vitro sustained release for up to six days. Drug content with NPs can be precisely tuned by\nchanging the initial drug feed concentration of ciprofloxacin. These studies suggest that this modified\nnanoprecipitation method is a rapid, facile, and reproducible technique for making nano-scale drug\ndelivery carriers with high drug-loading abilities
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